Jonny May, the 26-year-old Gloucester player will start on one wing and Marland Yarde on the other, with Semesa Rokoduguni missing out. Northampton’s Tom Wood has also been included in the 25-man squad for the match against the Springboks and is expected to start at open-side flanker, with Chris Robshaw and Billy Vunipola completing the back row. Wood has been recalled to the squad because of injuries to James Haskell, Maro Itoje, Jack Clifford, Sam Jones and Mike Williams.
Courtney Lawes will start in the second row alongside Joe Launchbury as England attempt to beat South Africa for the first time since 2006.
After facing South Africa, England will play Fiji, Argentina and Australia.
England are 1/6 to win on Saturday while the Springboks are 4/1 to triumph.
England squad to face South Africa:
Forwards: Josh Beaumont (Sale Sharks), Dave Attwood (Bath), Dan Cole (Leicester Tigers), Jamie George (Saracens), Dylan Hartley (Northampton Saints), Nathan Hughes (Wasps), Joe Launchbury (Wasps), Courtney Lawes (Northampton Saints), Joe Marler (Harlequins), Chris Robshaw (Harlequins), Kyle Sinckler (Harlequins), Tommy Taylor (Wasps), Billy Vunipola (Saracens), Mako Vunipola (Saracens), Tom Wood (Northampton Saints).
Backs: Mike Brown (Harlequins), Danny Care (Harlequins), Elliot Daly (Wasps), Owen Farrell (Saracens), George Ford (Bath), Jonathan Joseph (Bath), Jonny May (Gloucester), Ben Te’o (Worcester Warriors), Marland Yarde (Harlequins), Ben Youngs (Leicester Tigers).
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